What Is VDR?
VDR is a gene which encodes for a protein which acts as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of the gene (rs2228570, FokI polymorphism) is associated with a reduced bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the temporal and reciprocal pattern of on- and off occupancy of the VDRE by two components, and is affected by chromosomal location and binding preferences for specific hormones. Microarray studies in human cells show that more than 100 genes contain VDRE. The VDRE is occupied gescheftmarketing.de/2021/12/20/what-are-the-risks-in-using-a-file-sharing-system-vs-a-data-room-service/ by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for information and documents that are relevant to business, legal transactions or other activities that have limitations on viewing or downloading. It utilizes central computers and an extranet which is a restricted-access Internet connection, to allow users to login at specified times.
VDRs are most commonly used by investment banks and companies involved in mergers or acquisitions. They require to share information in a transparent manner with potential investors and buyers. Due diligence procedures can also require a substantial amount of data. Life science companies also use VDRs to store everything from clinical trials results to HIPAA documentation.